During the differentiation of these monocytes into DCs, IL-4-induced STAT6 phosphorylation decreases, as has been reported from a mouse model [20], and the levels of phosphorylated STAT6 in immature and mature Mo-DCs were similar in cells derived from CLL patients and healthy donors (Figure 4B). This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.