Aberrant expression of the HOXA cluster genes has also been reported in MLL-wt leukemias such as leukemias characterized by CALM-AF10 translocation, SET-NUP214 fusion and trisomy 8 AML, indicating that deregulation of this pathway might be a common driver in leukemogenesis [27–34]. The gene discussed is KMT2A; the disease is acute myeloid leukemia.