MYC and leukemia: CCI-007 was shown to reduce HOXA9, MEIS1, CMYC and BCL2 mRNA levels within a few hours after treatment in sensitive MLL-r (PER-485, MOLM-13, MV4;11) and CALM-AF10 leukemia (KP-MO-TS) cell lines, while the effects of CCI-007 treatment on expression levels of those genes in resistant leukemia cells were either minimal or absent (Figure 3A and Supplementary Figure S2).