A significant increase in the population of Annexin V-positive cells was detected in MLL-r cell lines sensitive to CCI-007 (PER-485, MOLM-13, MV4;11) upon CCI-007 treatment for 24h, while such an effect was not observed after treatment of CCI-007 resistant leukemia cell lines (CEM and RS4;11) (Figure 2A). This evidence concerns the gene KMT2A and leukemia.