Sensitivity was independent from the type of MLL translocation or the myeloid/lymphoid nature of the disease: all AML MLL-r cell lines (three out of three, namely MV4;11, MOLM-13 and THP-1 cells) were sensitive, while three out of eight ALL MLL-r cell lines were killed by the compound (PER-485, PER-490 and PER-703A). The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.