In a clinical study, Malaguarnera et al. investigated diabetes patients using a higher dose of LC supplementation of 2000 mg/d for 12 weeks and observed significant decreases in the levels of TC, TG, LDL-C, oxidized LDL-C, and Apo-B, and increases in the levels of HDL-C and Apo-A1 [20]. The gene discussed is APOB; the disease is diabetes mellitus.