We show in a murine model that concomitant exposure to a clinically relevant allergen (ie, HDM) and DEPs enhances several allergic airway responses, including airway eosinophilia, goblet cell metaplasia, increased ILC2 and TH2 cell numbers, type 2 cytokine production, and AHR. The gene discussed is AHR; the disease is Increased total eosinophil count.