Intriguingly, we found that the DEP-enhanced allergic airway inflammation only tended to decrease in RORαfl/flIL7RCre mice, whereas typical type 2 immune responses, such as eosinophilia, mucus metaplasia, and type 2 cytokine production, were completely abolished in Rag2−/− mice that received combined DEP+HDM. This evidence concerns the gene RAG2 and Increased total eosinophil count.