In accordance with our findings, several experimental and epidemiologic studies already provided evidence regarding the synergistic ability of DEPs in allergic airway inflammation.25, 27, 28, 29 Although these studies already demonstrated the enhanced effects on airway remodeling, AHR, eosinophilic inflammation, and immunoglobulin production, insights concerning the number and function of the recently identified ILC2s in response to concomitant exposure to DEP+HDM were lacking. The gene discussed is AHR; the disease is inflammation.