AHR and Increased total eosinophil count: Even in the absence of the adaptive immune system, ILC2s were able to mediate eosinophilia, goblet cell metaplasia, type 2 cytokine production, and AHR.17, 18, 19 In addition, mice that were ILC2 deficient because of targeting of the transcription factor RAR-related orphan receptor α (RORα) had decreased type 2 immune responses.14, 20, 21 Interestingly, it was reported that ILC2s and T cells interact with each other and that this crosstalk could contribute to the maintenance, proliferation, and activation of both ILC2s and TH2 cells.21, 22, 23