NLRP12 and Myalgia: Specifically, episodic fever, arthralgia, myalgia, and urticaria could be triggered by cold exposure in individuals carrying the p.R284X mutation in NLRP12. Recurrent bouts of fever and severe fatigue (musculo-skeletal symptoms) have been observed in patients carrying the p.F402L mutation in NLRP12. Notably, the p.R284X mutation in NLRP12 may be linked to sensorineural hearing loss.