In the current study, we investigated how CX3CL1‐CX3CR1 signaling influences microglia‐photoreceptor interactions in the well‐characterized rd10 mouse model of RP (Chang et al., 2007) where a point mutation in the rod photoreceptor‐specific Pde6b gene, which is also causative in human RP (McLaughlin et al., 1993), results in progressive photoreceptor degeneration. The gene discussed is PDE6B; the disease is retinitis pigmentosa 1.