Maintenance of appropriate levels of signaling may be pathogenically significant, as decreased CX3CR1 signaling has been related to worsened outcomes and increased microglial activation in a number of retinal disease models (Chen et al., 2013; Dagkalis et al., 2009; Kezic et al., 2013; Peng et al., 2014; Sennlaub et al., 2013; Wang et al., 2014; Zhang et al.,, 2012). This evidence concerns the gene CX3CR1 and Abnormal retinal morphology.