In brain neurodegenerative pathologies, CX3CL1‐CX3CR1 signaling is important in determining disease outcomes in models of Parkinson's disease (Cardona et al., 2006), multiple sclerosis (Garcia et al., 2013), and Alzheimer's disease (Cho et al., 2011; Fuhrmann et al., 2010). The gene discussed is CX3CL1; the disease is multiple sclerosis.