In the current study, we investigated how CX3CL1‐CX3CR1 signaling influences microglia‐photoreceptor interactions in the well‐characterized rd10 mouse model of RP (Chang et al., 2007) where a point mutation in the rod photoreceptor‐specific Pde6b gene, which is also causative in human RP (McLaughlin et al., 1993), results in progressive photoreceptor degeneration. This evidence concerns the gene CX3CL1 and retinitis pigmentosa 1.