In brain neurodegenerative pathologies, CX3CL1‐CX3CR1 signaling is important in determining disease outcomes in models of Parkinson's disease (Cardona et al., 2006), multiple sclerosis (Garcia et al., 2013), and Alzheimer's disease (Cho et al., 2011; Fuhrmann et al., 2010). Here, CX3CR1 is linked to early-onset autosomal dominant Alzheimer disease.