Recently, a study by Doukky et al. has been published that suggests that sodium restriction may increase hospitalizations in patients with NYHA II/III HF, especially in patients not receiving angiotensin-converting enzyme inhibitor or angiotensin receptor blocker (HR: 5.78; 95% CI: 1.93 to 17.27; p = 0.002), thus suggesting that sodium intake produces not only hemodynamic but also neurohormonal changes [135]. The gene discussed is ACE; the disease is hydrops fetalis.