Other genes associated with progression to NASH relate to oxidative stress and include the rs4880 variant of manganese-dependent superoxide dismutase (SOD2) gene, the rs1801278 variant of insulin receptor substrate-1 (IRS-1) and the rs3750861 variant of tumour suppressor gene Kruppel-like factor 6 (KLF-6) [55]. This evidence concerns the gene KLF6 and metabolic dysfunction-associated steatohepatitis.