For example, dietary supplementation with docosahexaenoic acid (DHA), the major dietary long-chain polyunsaturated (ω-3) fatty acid, which exerts a potent anti-inflammatory effect through the G protein-coupled receptor 120 (GPR-120), has been associated with significant improvement in the histological parameters of NAFLD, including NAFLD activity score, hepatocyte ballooning and steatosis in children, after 18 months [154]. This evidence concerns the gene FFAR4 and metabolic dysfunction-associated steatotic liver disease.