NCAN and obesity due to melanocortin 4 receptor deficiency: A recent genome-wide association study (GWAS) conducted by the Genetics of Obesity-Related Liver Disease Consortium identified robust associations between polymorphisms of the genes neurocan (NCAN), lysophospholipase-like 1 (LYPLAL1), glucokinase regulatory protein (GCKR) and protein phosphatase 1 regulatory subunit 3b (PPP1R3B) and NAFLD in adults of European ancestry [76].