Other genetic variants associated with NASH, hepatic fibrosis and the severity of liver damage in both adults and children have been described in genes involved in lipid metabolism, such as adiponutrin/patatin-like phospholipase domain-containing 3 (PNPLA3), Lipin 1 (LPIN1), adipoprotein C3 (APOC3), endocannabinoid receptor CB2, as well as the hereditary hemochromatosis (HFE) gene [55,82]. Here, LPIN1 is linked to Hepatic fibrosis.