Increasing evidence also suggests that adipose tissue fulfils important and distinct endocrine functions, producing multiple pro-inflammatory adipocytokines, including TNF-α, IL-6, leptin and adiponectin, which are implicated in the clinical manifestation of NAFLD and its progression to NASH and cirrhosis [37,38]. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatotic liver disease.