Other genetic variants associated with NASH, hepatic fibrosis and the severity of liver damage in both adults and children have been described in genes involved in lipid metabolism, such as adiponutrin/patatin-like phospholipase domain-containing 3 (PNPLA3), Lipin 1 (LPIN1), adipoprotein C3 (APOC3), endocannabinoid receptor CB2, as well as the hereditary hemochromatosis (HFE) gene [55,82]. This evidence concerns the gene LPIN1 and metabolic dysfunction-associated steatohepatitis.