Several studies have reported a predominance of CD8+ T cells over CD4+ and CD20+ subpopulations undergoing activation in paediatric NASH, in association with increased levels of IFN-γ within the hepatic microenvironment, a high number of infiltrating neutrophils in correlation with Reactive Oxygen Species (ROS) generation in peripheral neutrophils and further alterations in the phenotype and functionality of circulating lymphocytes and neutrophils compared with age-matched controls. This evidence concerns the gene CD8A and metabolic dysfunction-associated steatohepatitis.