Genes DC in at least two studies include many genes previously-associated with other neurodegenerative disorders, such as the genes FH, UBE2H and DLG1 that were found involved in Parkinson’s disease [28,36,44], KHDRBS2 recently implicated in Alzheimer’s disease [39], the gene PRKAR2A in Lewis body disease [37] and the TCP1 gene in Huntington’s disease [45]. This evidence concerns the gene UBE2H and early-onset autosomal dominant Alzheimer disease.