TFBSs overrepresented in the regulatory regions of DC and DE genes in both comparisons MS vs. HC and IFN-β-treated vs. untreated patients share at the top-ranked position the motif GGGCGGR, which matches the annotation for SP1. This finding is of particular interest, as Menon et al. have reported that specific targeting of SP1-dependent gene transcription in peripheral blood mononuclear cells by the inhibitor WP631 impaired T cell responses in vitro and in vivo and reduced the incidence and severity of experimental autoimmune encephalomyelitis [86]. This evidence concerns the gene IFNB1 and experimental autoimmune encephalomyelitis.