In the study of Riveros et al. [83], dysregulation by CREB/ATF, E2F families, ELK-1 and, principally, by MYB and YY1 is associated with MS overall, while E2F-1/DP-1 and E2F-4/DP-2 heterodimers, NF-kappaB (p65) and TTF-1 are specific for RRMS. This evidence concerns the gene CREB1 and myeloid sarcoma.