HERC5 and Autoimmunity: In the same direction, the recovered connectivity significantly pointed out known genes involved in the MS inflammatory cascade and the overall network of autoimmunity (AIM2, CXCL10, HERC5, IFI44L, ISG15, OASL, SUGT1, TRIM5); among them, the AIM2 gene, encoding an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to the activation of the ASC pyroptosome and caspase-1 and to pyroptotic neuronal cell death [66].