PTGS2 and neoplasm: Licoricidin administration caused a decrease in the expression of proteins related to (1) inflammation (HIF-1α, iNOS, and COX-2); (2) infiltration of macrophages, especially M2macrophages (CD45, F4/80, and CD206); (3) angiogenesis (CD31, VEGF-A, and VEGF-R2); and (4) lymphangiogenesis (LYVE-1, VEGF-C, and VEGF-R3) in tumor tissues (Figure 4A,B).