Researchers have used CYP2E1 knockout mice to evaluate the effect of CYP2E1 on ethanol-induced chronic liver injury, and the results showed that the fatty liver production and ethanol-induced oxidative stress of wild-type mice were significantly higher than those in CYP2E1 knockout mice [30], showing that CYP2E1 is involved in the oxidative stress of the body, increasing the severity of liver damage. The gene discussed is CYP2E1; the disease is injury.