Regrettably, mutations in the EGFR downstream signaling pathway (e.g. RAS mutations), can lead to constitutive RAS signaling, resulting in unresponsiveness to anti-EGFR therapy [4–6].The fact that in about 40% of patients with metastatic colorectal cancer (mCRC) mutations in the RAS gene can be observed, means that anti-EGFR therapy is applicable in only half of the mCRC patients [7]. Here, EGFR is linked to metastatic colorectal cancer.