With respect to Caco-2, SW480, SW620 and HT-29, the cytotoxic effect could be increased by cetuximab (Fig 4A), this enhancement of the cytolytic NK cell response was also evident from an increased rate of degranulation in the condition where NK cells and cetuximab were added in combination to EGFR+ colon cancer cell lines (Fig 4B). The gene discussed is EGFR; the disease is malignant colon neoplasm.