As can be seen in the S3A and S3B Fig, while NKG2A levels were comparable on NK cells in all donors that were tested, HLA-E expression levels were strikingly different and correlated with the overall susceptibility of tumor cells to NK cell lysis as shown in Fig 4, where cell lines with low HLA-E levels (COLO320, Caco-2, SW620) were more sensitive to NK cell killing compared to higher HLA-E expressing cell lines (SW480 and HT-29).These data suggest that NK cells have the potential to improve anti-EGFR mAb therapy efficacy even in situations where tumors carry RASmut, BRAFmut or are EGFR-. This evidence concerns the gene HLA-E and neoplasm.