Although some researchers as Lu in china and Lv in Uyghur ethnicity did not observe significant association of Ala589Ser for genotype and allelic frequency [19, 20], research conducted by Erlich and colleagues on Ala589Ser of WNK4 demonstrated that there was no association in genotype or in allele frequencies with hypertension among African American population [21]. This evidence concerns the gene WNK4 and Hypertension.