WNK4 and Hypertension: Guo et al. (2014) also pooled five studies in their meta-analysis; they managed to illustrate significant association between Ala589Ser of WNK4 and hypertension using both dominant genetic (OR = 51.85, 95% CI: 1.07–3.19, and p = 0.03) and allele contrast models (OR = 51.62, 95% CI: 1.11–2.38, and p = 0.01) [22].