The median levels of Runx2 in the RA group (20.42 ng/mL) were lower than those of the healthy controls (20.87 ng/mL) and the patients with AS (28.90 ng/mL), but all the differences did not reach statistical significance (p > 0.05, Figure 1(c)). This evidence concerns the gene RUNX2 and rheumatoid arthritis.