In chronic pancreatitis, using IL-10 knockout (KO) mice, Demols et al. have demonstrated that IL-10 could modulate proliferation and fibrosis in a cerulein-induced chronic pancreatitis mouse model [4], while in a nonalcoholic fatty pancreas disease mouse model, IL-10 secreted from spleen can downregulate the severity of inflammation [5]. Here, IL10 is linked to chronic pancreatitis.