The genetic variants in DNMT1, rs2114724 and rs2228611, were found to be significantly associated with schizophrenia while de novo DNMTs variants, DNMT3B rs2424932, DNMT3B rs156968, and DNMT3L rs2070565, were associated with early age onset of disease [195]. The gene discussed is DNMT3B; the disease is schizophrenia.