Likewise, in their in vitro study, they revealed that TMP suppresses the ox-LDL-induced activation of p-ERK, p-p38, and p-JNK MAPK. In vitro, HUVECs were stimulated with TNF-α, and two important indicators of autoimmunity, ICAM-1 and heat shock protein 60 (HSP60), were evaluated to determine the influence of TMP on HUVECS. This evidence concerns the gene HSPD1 and Autoimmunity.