MMP8 and Sepsis: Several studies have found associations between levels of MMP-8, MMP-9, MMP-10, and the MMP antagonist tissue inhibitor of metalloproteinases 1 (TIMP-1) and outcomes from sepsis in adults (86–88), while one study in a mixed population of ventilated adults found that serum levels of TIMP-1 and MMP-8 were associated with decreased survival and increased severity of hypoxemia (89).