Sung et al. demonstrated that C225 showed a significant single agent antitumor effect and an additive effect with cisplatin or paclitaxel in NPC cell lines with high EGFR protein expression (HK-1 and HONE-1) but a minimal activity in NPC cell lines with a low expression (CNE-2 and C666-1) [12]. The gene discussed is EGFR; the disease is nasopharyngeal carcinoma.