Evidence from well-designed network meta-analyses and clinical trials suggests that crystalloid fluids, particularly balanced solutions, seem to be the most advisable first choice, and albumin is equivalent or superior to other available fluids in severe sepsis and septic shock (Jacob et al. 2008; Rochwerg et al. 2015; Rochwerg et al. 2014; Delaney et al. 2011; SAFE Study Investigators et al. 2011). Here, ALB is linked to Sepsis.