VIM and breast cancer: EMT is crucial for the invasion and metastasis of breast cancer, and we have firstly showed that NC could inhibit cell migration and invasion of breast cancer MDA-MB-468 and MCF-7 cells, which was accompanied with upregulation of epithelial marker E-cadherin and downregulation of mesenchymal markers N-cadherin and Vimentin at the mRNA level (Fig. 2f).