Li et al. [24] and Rashid et al. [36] reported that topical omega-3 essential fatty acids (EFAs) decreased inflammatory markers such as CD11b+, IL-1α, IL-1β, IL-10, and TNF-α at both cellular and molecular levels and improved the corneal irregularity and staining scores of the murine dry eye model. This evidence concerns the gene IL1B and dry eye syndrome.