PPIB and Alzheimer disease: To a certain extent, it now becomes possible to aim at recapitulating AD “in a dish.” While iPSCs-derived cell models allowed the identification of factors associated with the disease phenotypes and the screening of various novel potential therapies, for example, the β- and γ-secretase inhibitors on the basis of the amyloid cascade hypothesis, there are still more discoveries to be made by using iPSC-derived models of AD (Figure 1).