Other rare variations were identified in genes coding for Netrin receptor, UNC5C [46], phospholipase D3 (PLD3) [47], ATP-binding cassette transporter (ABCA1) [48], and disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) [49, 50], although their functional participation in AD occurrence needs further investigation. The gene discussed is PLD3; the disease is Alzheimer disease.