Specifically, Ross et al. [24] implicated Wnt10b as the most important endogenous regulator of adipogenesis, while Longo et al. [26] showed that transgenic mice in which Wnt10b is expressed from the FABP4 promotor (FABP4-Wnt10b mice) had reduced adiposity and that FABP4-Wnt10b mice were resistant to diet-induced obesity. This evidence concerns the gene WNT10B and obesity due to melanocortin 4 receptor deficiency.