When dissecting the two main pathological machineries that affect retinopathy and nephropathy, applying ECFC with higher level of nitric oxide or Ang1 would be favorable for stabilized capillaries by reversing “uncoupled VEGF with nitric oxide,” balancing “Ang1/Ang2 competition” and “rendering Ang1/VEGF.” This idea awaits future evaluation. Here, ANGPT1 is linked to kidney disorder.