CLOCK and mood disorder: At the genetic component level of the circadian system, a study of 744 people who carry polymorphisms rs2291739 and rs11171856 from TIM, a member of the clock gene family which interacts with Per1-2 proteins [100, 101], showed that they have an elevated risk of developing mood disorders ranging between 19 and 23% (OR 1.19 and 1.23, resp).