Moreover, the authors reported the ancestral haplotypes for Per3 rs228729, rs228727, rs707467, rs228644, and rs10462020 are associated with a higher cancer frequency [83]; similarly, a meta-analysis performed by literature search showed that the variant insertion/deletion of Per3 rs57875989 is associated with an increase of cancer susceptibility in about 17% [80] or 70% [81]. This evidence concerns the gene PER3 and cancer.