Moreover, exogenous Clock inhibits the apoptosis (42% reduction) via inhibition on apoptosis associated proteins expression of Bax and Bid and the increase of phosphorylation of Akt [111]. In vivo experiments by xenograft transplant of colorectal carcinoma cell line transduced with clock increase the tumor volume and tumor weight in about 61% and a 91%, respectively [111]. Here, AKT1 is linked to neoplasm.