PER3 and prostate carcinoma: Similarly, a genotyping of a patient with prostate cancer showed a strong correlation between Cry1 polymorphisms rs7297614, rs1921126, and rs12315175 and fatal prostate cancer (OR mean within 1.5–2) [85] and a study conducted in China showed that the Cry2 variant rs1401417 and the deletion/insertion of 54 base pair sequences on Per3 gene (rs57875989) were associated with a major risk of developing prostate cancer (OR; 1.7 and 1.3, resp).