The relationship between PPARγ and DM2 has been established using both in vitro and in vivo experimentation, since it has been seen that the inactivation of PPARγ in mature adipocytes leads to insulin resistance, as mice lacking the receptor develop hyperlipidemia, hyperglycemia, and/or hyperinsulinemia [26, 27]. The gene discussed is PPARG; the disease is Hyperinsulinemia.