All three isotypes of PPARs, but mainly PPARγ, are ligand activated transcription factors implicated in the physiopathology of various diseases including DM2, obesity, dyslipidemia, atherosclerosis, neoplastic diseases, tumors, inflammatory conditions, and neurodegenerative diseases by forming obligate heterodimers with the retinoid X receptor (RXR), promoting the dissociation of corepressors, recruitment of coactivators, and the subsequent transcription of target genes [3, 6, 12, 13, 36–42]. This evidence concerns the gene PPARG and myotonic dystrophy type 2.