PPARs have emerged as links between lipids, metabolic diseases, and innate immunity as they regulate energy homeostasis [25, 26], and, specifically talking about PPARγ, this receptor is capable of regulating metabolic genes which will be further discussed and improves insulin sensitivity through glucose and lipid uptake and storage in peripheral tissues such as skeletal muscle, liver, and adipose tissue [26]. This evidence concerns the gene INS and metabolic disease.