INS and Hyperglycemia: The treatment of type 2 diabetes mellitus (DM2) has been directed toward the reduction of hyperglycemia and glycosylated hemoglobin (HbA1c, ≤7%), in order to prevent cardiovascular and other long term risks [1, 2], specially by the usage of insulin sensitizers such as thiazolidinediones (TZDs) [1–5], an effective type of drugs for lowering blood glucose levels as circulating triglycerides [4, 6–9], with adverse effects such as adipocyte differentiation, fluid retention, weight gain, bone loss, and congestive heart failure [6–8, 10–13].