IL-1β is often a crucial mediator of cartilage destruction in arthritis models (80), and after induction of K/BxN STA, IL-1R KO mice showed, in addition to complete arthritis suppression, no signs of cartilage destruction (57), suggesting that IL-1β is a crucial driver of cartilage destruction also in this model. The gene discussed is IL1R1; the disease is arthritic joint disease.