BDNF has been shown to inhibit apoptosis in rat retinal ganglion cells at early stages of DR and it has been shown that BDNF protects retinal neurons from hyperglycemia through the Tropomyosin-related kinase B (TrkB)/ERK/MAPK pathway (Liu et al., 2013). The gene discussed is NTRK2; the disease is Hyperglycemia.