FHM is a genetically heterogeneous disease, in which mutations can occur in the ion transportation genes CACNA1A, ATP1A2, and SCN1A (Rogawski, 2008), promoting the different types of familial migraines, FHM1, FHM2 and FHM3 (Russell et al., 1994; Pierelli et al., 2006; Deprez et al., 2008). This evidence concerns the gene SCN1A and familial hemiplegic migraine.