ACTA1 and Hepatic fibrosis: Treatment of rat AAF/CCl4 fibrotic model with chloroquine, which blocks autophagic degradation in the lysosome, also ameliorated liver injury, decreased the expression of CK19 and pro-fibrogenic targets (COL1A1, α-SMA, TGF-β), and blunted liver fibrosis (Hung et al., 2015).