Experimental and human diabetes are associated with high urinary levels of soluble active ACE2 fragments, implicating a role for ACE2 shedding as a biomarker of disease activity (Mizuiri et al., 2011; Xiao et al., 2012; Chodavarapu et al., 2013; Park et al., 2013; Wysocki et al., 2013; Cherney et al., 2014; Salem et al., 2014). This evidence concerns the gene ACE2 and diabetes mellitus.