Although the RANKL/RANK axis has undoubtedly been considered to be an essential factor for osteoclastogenesis that occurs in the bone remodeling physiologic process, tumor necrosis family superfamily members are known to influence osteoclast formation and bone resorption by a RANKL-independent mechanism (Sabokbar et al., 2015; Yuan et al., 2015). This evidence concerns the gene TNFSF11 and neoplasm.