These findings are consistent with other research that has linked methylation in these early NR3C1 CpG sites to poor stress response in humans and animal models (Weaver et al., 2004; Oberlander et al., 2008), and to neurobehavioral risks such as premature birth (Lester et al., 2015) and maternal anxiety and depression during pregnancy (Oberlander et al., 2014). This evidence concerns the gene NR3C1 and depressive disorder.