NR3C1 and major depressive disorder: These findings are consistent with other research that has linked methylation in these early NR3C1 CpG sites to poor stress response in humans and animal models (Weaver et al., 2004; Oberlander et al., 2008), and to neurobehavioral risks such as premature birth (Lester et al., 2015) and maternal anxiety and depression during pregnancy (Oberlander et al., 2014).