INS and metabolic syndrome: While the biological function of the variants within COBLL1 and MACF1 is unknown, exploration of the functional effects of the risk variant rs72836561 at CD300LG revealed that this polymorphism is associated with reduced mRNA expression of CD300LG in skeletal muscle and adipose tissue, decreased insulin sensitivity and increased intramyocellular lipid content suggesting a link between this variant and aspects of the metabolic syndrome [68].