IRS1 and Insulin resistance: Scott and colleagues generated an insulin resistance risk score from ten variants which were also specifically associated with lower HDL and higher triglycerides (IRS1, GRB14, ARL15, PPARG, PEPD, ANKRD55-MAP3K1, PDGFC, LYPLAL1, RSPO3 and FAM13A1) while Yaghootkar and colleagues selected 19 variants to generate their insulin resistance risk score.