We found that HIF-1α was present in the cytoplasm of T-cell leukaemia Jurkat cells and was subjected to DAPK regulation (Figs 4e and 5e), suggesting that DAPK likely exhibits a tumour suppressor effect in T leukaemia cells by directly binding to the cytosolic HIF-1α to prompt HIF-1α downregulation. The gene discussed is DAPK1; the disease is neoplasm.