Enhanced GPVI expression is also seen after ischemic stroke and TIA, with these patients having a poorer clinical outcome at follow-up.30 Elevated sGPVI levels were found in patients specifically after large artery infarcts and these levels decrease after 3–6 months, which may highlight a role for sGPVI measurements in this stroke substrate, but the evidence in cardioembolic and lacunar types were less convincing.31 This evidence concerns the gene GP6 and ischemic stroke.