GP6 and brain infarction: After tMCAO, GPVI-depleted mice (via JAQ1) demonstrate significantly reduced brain infarct volumes, no hemorrhagic transformation, normal platelet counts, and only moderately increased tail bleeding times.28,43 As platelets are anucleate cells and cannot synthesis protein de novo, injection of rat anti-GPVI antibodies (JAQ 1, 2, and 3) into mice in other studies offered long-term depletion of GPVI from murine platelet surfaces.28,44 Furthermore, the Fab fragments of antibodies 5C4,45 OM2,46 OM4,47 9O12,48 and mFab-F16 are also potent inhibitors of GPVI-mediated platelet activation (Table 1).