FGF21 and obesity due to melanocortin 4 receptor deficiency: Although β-conglycinin slightly prevented body weight gain even in FGF21-deficient mice, its anti-obesity effect was prominent in WT mice despite the fact that daily intake of the β-conglycinin diet was slightly but rather significantly higher, suggesting that FGF21 largely contributed to preventing body weight gain (Fig. 2a–c).