CYP1A2 and Hypoglycemia: At the enzyme activity level, CYP1A2 and CYP2A6 were not affected under hypoglycemia as compared to normoglycemia; however, hypoglycemia led to a significant (up to 2.3 fold) increase in CYP3A4 activity, an enzyme involved in the metabolism of >50% of drugs on the market32.