Since the upregulation of asparagine synthetase resulted in drug resistance in acute lymphoblastic leukaemia during chemotherapy (Aslanian et al., 2001), and a high asparagine synthetase expression level was detected in prostate cancer and was also related to aggressiveness of gliomas (Sircar et al., 2012, Panosyan et al., 2014), the detailed study of the regulation of asparagine synthetase may have important clinic implications. This evidence concerns the gene ASNS and acute lymphoblastic leukemia.