RHOA and melanoma: Other promising novel candidates include the promoters of SYF2 (details in Fig. 3c), an mRNA splicing factor thought to interact with a cell cycle regulator [23], ARHGEF18, a Rho-specific guanine nucleotide exchanging factor involved in RhoA activation and cell motility [24], and POLR2D (Fig. 3d), a subunit of the RNA polymerase, which contains mutations very close to the transcription start site (TSS) in melanoma samples [25, 26].