In order to control if the lack of IL-22 during PbA infection is associated with increased inflammation in the liver ALT (Fig. 2E) and AST (Fig. 2F) levels were analysed in PbA iRBC-infected wt and Il22−/− mice at d6 p.i. Even though an induction of ALT was observed in PbA iRBC-infected wt mice compared to the naive group, there were no differences visible during PbA iRBC infection between wt and Il22−/− mice. The gene discussed is GPT; the disease is infection.