ATRX and central nervous system cancer: In univariate analyses, ATRX loss in low grade gliomas was significantly associated with a better survival (Fig. 3a, WHO II: p = 0.0059; HR = 1.75, 95CI = 1.17–2.63) but not in high-grade tumors (WHO III: p = 0.09; WHO IV: p = 0.35).