H3-3A and central nervous system cancer: Frequent alterations in the genes involved chromatin remodelling pathways in gliomas, e.g., recurrent mutations in H3 histone, family 3A (H3F3A) and α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX), a chromatin modifier, have been identified in paediatric gliomas [8].