Although a previous study suggested a single nucleotide polymorphism (SNP) of CASR (rs1801725) as a predictor of CV mortality in 2561 Europeans with coronary artery disease, no association between variants of the CASR locus was observed in a genome-wide association meta-analysis of 39,400 individuals.[37] Further studies are needed to determine the genetic influence of other potential genes such as CSTA, DGKD, GCKR, and other variants of CASR. [38] The results of the present study have important clinical implications. The gene discussed is GCKR; the disease is coronary artery disorder.