In the Leeds Family Study, ACE, ACE2, and neutral endopeptidase (NEP) activities were measured in plasma from 534 subjects and it was indicated that up to 67% of the phenotypic variation in circulating ACE2 could be accounted for by genetic factors.[12] Some genotype association studies indicated that single-nucleotide polymorphisms (SNPs) in the ACE2 gene were related with cardiovascular diseases. The gene discussed is MME; the disease is cardiovascular disorder.