GNRH1 and Stroke: In synthesis, we observed an increased risk for stroke with CAB compared to AA (RR, 1.10 [1.02–1.19]); an increased risk for MI with GnRH agonist when compared to AA (RR, 1.43 [1.10–1.85]) and a consistent statistically nonsignificant association as regards stroke (RR, 1.22 [0.93–1.61]); thus AA appeared associated with a lower CV risk than GnRH alone or CAB.