Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are major inflammatory cytokines involved in the pathogenesis of BD.[5] TNF-α production is elevated in the intestinal tissues of intestinal BD patients[6] and in peripheral blood cells of VBD patients,[7] while IL-6 concentrations are elevated in the cerebrospinal fluid (CSF) of NBD patients.[8]. The gene discussed is TNF; the disease is Behcet disease.