Type 2 diabetes, age >75 years, and renal impairment were included as these variables showed a close association with a coexisting CLI in studies published recently from our group[13,14] and CRP was included as this is an established parameter reflecting vascular inflammation.[15] Even after adjustment for these parameters AAR > 1.67 was associated with an OR of 2.0 (95%confidence interval 1.7–2.3, P < 0.001) for CLI (Table 3). This evidence concerns the gene CRP and type 2 diabetes mellitus.