9, 33 Similarly, p53 was initially believed to be an oncogene because of its overexpression in cancer, but later on found to be a tumor suppressor frequently inactivated in cancer, where the mutations cause overexpression of inactive p53 owing to reduced degradation of the protein.34 In any case, understanding the function of WRAP53β in health and diseases, such as cancer, may open novel therapeutic strategies. The gene discussed is TP53; the disease is neoplasm.