BCL2 and cancer: We showed earlier that knockdown of WRAP53β in cancer cell lines, including the U2OS cells examined here, triggers mitochondria-dependent apoptosis and that overexpression of Bcl-2 protects against this apoptosis.16 Thus, Bcl-2 and/or other antiapoptotic proteins may be upregulated in cells that overexpress WRAP53β, protecting them from apoptosis.