TCF7L2 and colorectal carcinoma: To further support the hypothesis that expression of MUCDHL is negatively regulated by active β-catenin, we treated the CaCo2 and HCT116 CRC cell lines with the FH535 compound, which inhibits the β-catenin pathway through complete silencing of the β-catenin-regulated transcription factor 7-like 2 (TCF4) transcription factor.